- Eager, Ben
- Earnhardt Jr., Dale
- Earnhardt Sr., Dale
- Easley, Damion
- Eaton, Adam
- Eaton, Mark
- Echevarria, Angel
- Eckenrode, Jack
- Eckstein, David
- Edberg, Stefan
- Edinger, Paul
- Edmonds, Jim
- Edney, Tyus
- Edsall, Randy
- Edwards, Brian
- Edwards, David
- Edwards, Donnie
- Edwards, Marc
- Edwards, Robert
- Edwards, Troy
- Egbert, Jack
- Eichelberger, Dave
- Eisley, Howard
- Ekman, Nils
- Ekuban, Ebenezer
- Elam, Jason
- Elarton, Scott
- Elias, Patrik
- Elkington, Steve
- Elliott, Jamelle
- Elliott, John
- Elliott, Jumbo
- Elliott, Sean
- Ellis, Robert
- Ellis, Shaun
- Ellsbury, Jacoby
- Ellsworth, Percy
- Els, Ernie
- Emanuel, Bert
- Emerson, Roy
- Emmons, Carlos
- Encarnacion, Juan
- Engelberger, John
- Engram, Bobby
- Erstad, Darin
- Esche, Robert
- Escobar, Kelvim
- Eskandarian, Alecko
- Estes, Bob
- Estes, Shawn
- Estrada, Johnny
- Evans, Billy
- Evans, Demetric
- Evans, Doug
- Evans, Josh
- Evans, Michael
- Evans, Troy
- Everett, Carl
- Evers, Johnny
- Evert, Chris
- Ewbank, Weeb
- Ewing, Patrick
- Eyre, Scott