AUSTIN -- The U.S. Anti-Doping Agency said last night it will strip Lance Armstrong of his unprecedented seven Tour de France titles after he declared he was finished fighting the drug charges that threaten his legacy as one of the greatest cyclists of all time.

Travis Tygart, USADA's chief executive, said Armstrong would also be hit with a lifetime ban today.

Still to be heard from was the sport's governing body, the International Cycling Union, which had backed Armstrong's legal challenge to USADA's authority.

Armstrong, who retired last year, declined to enter USADA's arbitration process -- his last option -- because he said he was weary of fighting accusations that have dogged him for years. He has consistently pointed to the hundreds of drug tests that he has passed as proof of his innocence during his extraordinary run of Tour titles stretching from 1999-2005.

"There comes a point in every man's life when he has to say, 'Enough is enough.' For me, that time is now," Armstrong said in a statement sent to The Associated Press. He called the USADA investigation an "unconstitutional witch hunt."

USADA reacted quickly and treated Armstrong's decision as an admission of guilt, hanging the label of drug cheat on an athlete who was a hero to thousands for overcoming life-threatening testicular cancer and for his foundation's support for cancer research.

"It is a sad day for all of us who love sport and athletes," Tygart said. "It's a heartbreaking example of win at all costs overtaking the fair and safe option. There's no success in cheating to win." He said the agency can strip the Tour titles, though Armstrong disputed that as he insisted his decision is not an admission of drug use, but a refusal to enter an arbitration process he believes is unfair.

"USADA cannot assert control of a professional international sport and attempt to strip my seven Tour de France titles," Armstrong said. "I know who won those seven Tours, my teammates know who won those seven Tours, and everyone I competed against knows who won those seven Tours."

USADA maintains that Armstrong has used banned substances as far back as 1996, including the blood-booster EPO and steroids as well as blood transfusions -- all to boost his performance.

Armstrong, 40, walked away from the sport last year without being charged following a two-year federal criminal investigation into many of the same accusations he faces from USADA.

The federal probe was closed in February, but USADA announced in June it had evidence Armstrong used banned substances and methods and encouraged their use by teammates.

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