Arizona Cardinals quarterback Kyler Murray (1) throws the ball as...

Arizona Cardinals quarterback Kyler Murray (1) throws the ball as Cardinals guard Will Hernandez (76) blocks Buffalo Bills defensive tackle Austin Johnson (98) during the first half of an NFL football game Sunday, Sept. 8, 2024, in Orchard Park, N.Y. Credit: AP/Matt Slocum

TEMPE, Ariz. — Arizona Cardinals offensive lineman Will Hernandez is out for the season because of a knee injury he suffered in the team's 24-23 win over the San Francisco 49ers on Sunday.

Coach Jonathan Gannon confirmed the extent of the injury on Monday, saying Hernandez would go on injured reserve. The 29-year-old has started 33 games for the Cardinals over the past three seasons as a mainstay at right guard.

“Will was playing really well for us,” Gannon said. “He's an integral part of our toughness and attitude. It's a tough one to lose.”

The Cardinals are already without starting right tackle Jonah Williams, who is on IR with a knee injury.

Gannon said rookie defensive lineman Darius Robinson and receiver Zay Jones would return to the practice this week. Robinson — the No. 27 overall pick out of Missouri — hasn't played yet this season because of a calf injury suffered during the preseason.

Jones was suspended without pay for the first five games for violating the NFL’s personal conduct policy.

The Cardinals (2-3) play their second straight road game against the Green Bay Packers on Sunday.

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